Predicted protein targets (top 13)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.67 |
| ▸ | FBP1 | P09467 | 2/20 | 0.67 |
| ▸ | KDR | P35968 | 2/20 | 0.67 |
| ▸ | AURKA | O14965 | 1/20 | 0.67 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.67 |
| ▸ | INSR | P06213 | 1/20 | 0.67 |
| ▸ | PDGFRB | P09619 | 1/20 | 0.67 |
| ▸ | FLT4 | P35916 | 1/20 | 0.67 |
| ▸ | CLK1 | P49759 | 1/20 | 0.67 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.67 |
| ▸ | TEK | Q02763 | 1/20 | 0.67 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.67 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.62 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12788058 | 0.86 | EGFR (0.72) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL28403915 | 0.84 | EGFR (0.74) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL21083167 | 0.82 | EGFR (0.75) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL12788062 | 0.82 | EGFR (0.66) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL14444601 | 0.82 | EGFR (0.66) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL7543155 | 0.81 | GRM1 (0.74) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL8311292 | 0.81 | EGFR (0.77) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL5843772 | 0.81 | EGFR (0.69) | EGFRFBP1KDRAURKAERBB2 | |
| Hydrochloric Acid SCHEMBL7537987 | 0.81 | GRM1 (0.72) | EGFRFBP1KDRAURKAERBB2 | |
| SCHEMBL7802281 | 0.81 | EGFR (0.67) | EGFRFBP1KDRAURKAERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | claimed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | claimed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | claimed |
| EP-0635507-B1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LTD (GB) | 1999-09-15 | — | — | EP | disclosed |
| US-5569658-A | Tricyclic derivatives | ZENECA LIMITED (GB) | 1996-10-29 | — | — | US | disclosed |
| EP-0635507-A1 | Tricyclic derivatives and their use as anti-cancer agents | ZENECA LIMITED (GB) | 1995-01-25 | — | — | EP | disclosed |