Predicted protein targets (top 15)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.41 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.41 |
| ▸ | CTSL | P07711 | 3/20 | 0.41 |
| ▸ | CTSS | P25774 | 1/20 | 0.41 |
| ▸ | CTSK | P43235 | 1/20 | 0.41 |
| ▸ | UGCG | Q16739 | 2/20 | 0.40 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TACR1 | P25103 | 2/20 | 0.40 |
| ▸ | MCL1 | Q07820 | 1/20 | 0.39 |
| ▸ | TACR2 | P21452 | 1/20 | 0.39 |
| ▸ | TP53 | P04637 | 1/20 | 0.39 |
| ▸ | MAPT | P10636 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312093 | 1.00 | MEN1 (0.46) | MEN1KMT2AHDAC1HDAC8CTSL | |
| SCHEMBL8311537 | 0.87 | MEN1 (0.48) | MEN1KMT2AHDAC1HDAC8CTSL | |
| SCHEMBL8311541 | 0.87 | MEN1 (0.48) | MEN1KMT2AHDAC1HDAC8CTSL | |
| Trifluoroacetic Acid SCHEMBL8522196 | 0.86 | TACR2 (0.42) | MEN1KMT2AUGCGCYP3A4TACR1 | |
| Trifluoroacetic Acid SCHEMBL8522197 | 0.86 | TACR2 (0.42) | MEN1KMT2AUGCGCYP3A4TACR1 | |
| SCHEMBL8311927 | 0.85 | MEN1 (0.46) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL8311930 | 0.85 | MEN1 (0.46) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL8311887 | 0.84 | MEN1 (0.47) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL8311885 | 0.84 | MEN1 (0.47) | MEN1KMT2ACTSLCTSSCTSK | |
| SCHEMBL8313873 | 0.84 | MEN1 (0.43) | MEN1KMT2AHDAC1HDAC8CTSL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |