Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK1 | P06493 | 3/20 | 0.54 |
| ▸ | CDK2 | P24941 | 3/20 | 0.54 |
| ▸ | JAK2 | O60674 | 8/20 | 0.48 |
| ▸ | JAK3 | P52333 | 7/20 | 0.48 |
| ▸ | IKBKB | O14920 | 3/20 | 0.48 |
| ▸ | CHUK | O15111 | 3/20 | 0.48 |
| ▸ | JAK1 | P23458 | 2/20 | 0.48 |
| ▸ | TYK2 | P29597 | 2/20 | 0.48 |
| ▸ | HDAC1 | Q13547 | 2/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.48 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.48 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.48 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.48 |
| ▸ | MTOR | P42345 | 1/20 | 0.47 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.47 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.46 |
| ▸ | IKBKG | Q9Y6K9 | 1/20 | 0.46 |
| ▸ | DYRK2 | Q92630 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14021289 | 0.92 | CDK1 (0.51) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021288 | 0.92 | CDK1 (0.51) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021585 | 0.87 | CDK1 (0.53) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021571 | 0.85 | CDK1 (0.66) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL8205109 | 0.85 | CDK2 (0.55) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021564 | 0.84 | MTOR (0.60) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021582 | 0.84 | GAA (0.58) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021606 | 0.83 | IKBKB (0.53) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021591 | 0.83 | CDK2 (0.53) | CDK1CDK2JAK2JAK3IKBKB | |
| SCHEMBL14021578 | 0.82 | JAK2 (0.64) | CDK2JAK2JAK3JAK1TYK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |