Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 10/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 9/20 | 0.64 |
| ▸ | RAB9A | P51151 | 5/20 | 0.64 |
| ▸ | NPC1 | O15118 | 3/20 | 0.64 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.64 |
| ▸ | HPGD | P15428 | 3/20 | 0.55 |
| ▸ | LMNA | P02545 | 5/20 | 0.54 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.54 |
| ▸ | CYP2C19 | P33261 | 2/20 | 0.54 |
| ▸ | RECQL | P46063 | 2/20 | 0.54 |
| ▸ | ALOX12 | P18054 | 1/20 | 0.54 |
| ▸ | POLB | P06746 | 3/20 | 0.51 |
| ▸ | SMN1; SMN2 | Q16637 | 3/20 | 0.51 |
| ▸ | HSP90AA1 | P07900 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 3/20 | 0.50 |
| ▸ | MEN1 | O00255 | 1/20 | 0.48 |
| ▸ | GAA | P10253 | 3/20 | 0.47 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL11462210 | 0.81 | MAPT (0.76) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL11462209 | 0.81 | MAPT (0.76) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL15183943 | 0.80 | MAPT (0.69) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL23251385 | 0.79 | MAPT (0.81) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL801295 | 0.78 | MAPT (0.62) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL4070316 | 0.77 | MAPT (0.60) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL4070320 | 0.77 | MAPT (0.60) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL31276086 | 0.77 | MAPT (0.69) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL5475341 | 0.77 | MAPT (0.69) | MAPTALDH1A1RAB9ANPC1KMT2A | |
| SCHEMBL23574721 | 0.76 | MAPT (0.82) | MAPTALDH1A1RAB9ANPC1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349840-B1 | ANILINOPYRIMIDINE DERIVATIVES AS JNK PATHWAY INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-03-11 | — | — | EP | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |