Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 6/20 | 0.51 |
| ▸ | CHUK | O15111 | 6/20 | 0.51 |
| ▸ | IKBKG | Q9Y6K9 | 5/20 | 0.51 |
| ▸ | CDK2 | P24941 | 3/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | JAK2 | O60674 | 8/20 | 0.44 |
| ▸ | SYK | P43405 | 2/20 | 0.44 |
| ▸ | JAK3 | P52333 | 4/20 | 0.43 |
| ▸ | CDK9 | P50750 | 2/20 | 0.43 |
| ▸ | AURKA | O14965 | 1/20 | 0.43 |
| ▸ | CDK4 | P11802 | 1/20 | 0.43 |
| ▸ | CDK7 | P50613 | 1/20 | 0.43 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.43 |
| ▸ | PLK4 | O00444 | 1/20 | 0.43 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.43 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.43 |
| ▸ | CCNA1 | P78396 | 1/20 | 0.43 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.43 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.43 |
| ▸ | JAK1 | P23458 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312555 | 0.92 | IKBKB (0.52) | IKBKBCHUKIKBKG | |
| SCHEMBL8311749 | 0.90 | IKBKB (0.55) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL8308936 | 0.90 | CDK2 (0.47) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL14063857 | 0.89 | IKBKB (0.49) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL8311902 | 0.88 | IKBKB (0.50) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL5070979 | 0.88 | IKBKB (0.47) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL14063867 | 0.87 | JAK2 (0.46) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL8313335 | 0.87 | IKBKB (0.49) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL14063861 | 0.87 | IKBKB (0.47) | IKBKBCHUKIKBKGCDK2CDK1 | |
| SCHEMBL14063864 | 0.87 | IKBKB (0.47) | IKBKBCHUKIKBKGCDK2CDK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |