Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPK8 | P45983 | 3/20 | 0.77 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.77 |
| ▸ | PIK3CG | P48736 | 5/20 | 0.66 |
| ▸ | PIK3CA | P42336 | 3/20 | 0.66 |
| ▸ | PIK3CB | P42338 | 2/20 | 0.66 |
| ▸ | JAK2 | O60674 | 3/20 | 0.65 |
| ▸ | CAMKK2 | Q96RR4 | 5/20 | 0.64 |
| ▸ | GSK3B | P49841 | 3/20 | 0.64 |
| ▸ | IKBKB | O14920 | 2/20 | 0.63 |
| ▸ | CAMK2D | Q13557 | 4/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.60 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | CDK2 | P24941 | 2/20 | 0.54 |
| ▸ | KCNH2 | Q12809 | 1/20 | 0.54 |
| ▸ | CDK4 | P11802 | 1/20 | 0.54 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.53 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.53 |
| ▸ | JAK1 | P23458 | 1/20 | 0.53 |
| ▸ | TYK2 | P29597 | 1/20 | 0.53 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL4800404 | 0.88 | MAPK8 (0.83) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL4070306 | 0.87 | MAPK8 (0.77) | MAPK8MAPK10PIK3CGPIK3CAPIK3CB | |
| SCHEMBL13911421 | 0.87 | MAPK8 (0.77) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL13911478 | 0.87 | MAPK8 (0.77) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL4903457 | 0.87 | MAPK8 (0.81) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL8246523 | 0.87 | MAPK8 (1.00) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL8314313 | 0.84 | MAPK8 (0.72) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL14020940 | 0.84 | MAPK8 (0.72) | MAPK8MAPK10PIK3CGJAK2CAMKK2 | |
| SCHEMBL14021043 | 0.84 | PIK3CG (0.62) | MAPK8MAPK10PIK3CGPIK3CAPIK3CB | |
| SCHEMBL8313286 | 0.83 | PIK3CG (0.71) | MAPK8MAPK10PIK3CGPIK3CAPIK3CB |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 6 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349841-B1 | ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-12-02 | — | — | EP | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |