Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TP53 | P04637 | 1/20 | 0.64 |
| ▸ | ALDH1A1 | P00352 | 4/20 | 0.45 |
| ▸ | KDM4E | B2RXH2 | 2/20 | 0.45 |
| ▸ | TAS2R14 | Q9NYV8 | 1/20 | 0.45 |
| ▸ | CA2 | P00918 | 3/20 | 0.43 |
| ▸ | MEN1 | O00255 | 1/20 | 0.43 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.43 |
| ▸ | PSIP1 | O75475 | 1/20 | 0.43 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | GAA | P10253 | 1/20 | 0.42 |
| ▸ | BLM | P54132 | 1/20 | 0.42 |
| ▸ | GFER | P55789 | 1/20 | 0.42 |
| ▸ | PMP22 | Q01453 | 1/20 | 0.42 |
| ▸ | PPARG | P37231 | 1/20 | 0.42 |
| ▸ | PPARA | Q07869 | 1/20 | 0.42 |
| ▸ | CA1 | P00915 | 2/20 | 0.42 |
| ▸ | MMP1 | P03956 | 1/20 | 0.42 |
| ▸ | MMP2 | P08253 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Ethylbenzene SCHEMBL1818291 | 0.91 | TP53 (0.70) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL6362282 | 0.91 | TP53 (0.70) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL28415040 | 0.88 | TP53 (0.67) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL8824343 | 0.88 | TP53 (0.67) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL1061730 | 0.88 | TP53 (0.67) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL28830052 | 0.88 | TP53 (0.67) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL11127609 | 0.86 | TP53 (0.64) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL29109621 | 0.84 | TP53 (0.61) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL28419127 | 0.84 | TP53 (0.61) | TP53ALDH1A1KDM4ETAS2R14CA2 | |
| Ethylbenzene SCHEMBL28929180 | 0.84 | TP53 (0.61) | TP53ALDH1A1KDM4ETAS2R14CA2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0733626-B1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GMBH (DE) | 1999-01-13 | — | — | EP | disclosed |
| EP-0733626-A1 | N-(Benzofuranazyl)-arylsulphonamides and their analogues useful as endothelin-receptor-antagonists | MERCK PATENT GmbH (DE) | 1996-09-25 | — | — | EP | disclosed |
| EP-0031954-B1 | SULPHONAMIDES, PROCESS FOR THEIR PREPARATION AND MEDICINES CONTAINING THESE COMPOUNDS | Roche Diagnostics GmbH (DE) | 1984-03-14 | — | — | EP | disclosed |
| EP-0031954-A2 | Sulphonamides, process for their preparation and medicines containing these compounds | Roche Diagnostics GmbH (DE) | 1981-07-15 | — | — | EP | disclosed |
| US-3932419-A | QUINOLINE DYES | BAYER AKTIENGESELLSCHAFT (DT) | 1976-01-13 | — | — | US | disclosed |