Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC1 | Q13547 | 8/20 | 0.61 |
| ▸ | NPC1 | O15118 | 5/20 | 0.55 |
| ▸ | POLB | P06746 | 2/20 | 0.55 |
| ▸ | MEN1 | O00255 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.55 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.55 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.51 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.51 |
| ▸ | TSHR | P16473 | 1/20 | 0.51 |
| ▸ | HSD17B10 | Q99714 | 1/20 | 0.51 |
| ▸ | NOTUM | Q6P988 | 1/20 | 0.51 |
| ▸ | RAB9A | P51151 | 4/20 | 0.50 |
| ▸ | PABPC1 | P11940 | 1/20 | 0.50 |
| ▸ | HDAC6 | Q9UBN7 | 4/20 | 0.48 |
| ▸ | HDAC4 | P56524 | 3/20 | 0.48 |
| ▸ | HDAC3 | O15379 | 2/20 | 0.48 |
| ▸ | HDAC7 | Q8WUI4 | 2/20 | 0.48 |
| ▸ | HDAC2 | Q92769 | 2/20 | 0.48 |
| ▸ | HDAC10 | Q969S8 | 2/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8083047 | 0.86 | HDAC1 (0.72) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL8094598 | 0.84 | HDAC1 (0.76) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL8083036 | 0.80 | HDAC1 (0.79) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL13034819 | 0.78 | NPC1 (0.70) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL29944526 | 0.76 | NPC1 (0.77) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL5142389 | 0.76 | NPC1 (0.77) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL8361569 | 0.76 | HDAC1 (1.00) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL8402849 | 0.75 | NPC1 (0.70) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL13338207 | 0.75 | NPC1 (0.62) | HDAC1NPC1POLBMEN1MAPT | |
| SCHEMBL3545217 | 0.74 | NPC1 (0.65) | HDAC1NPC1POLBMEN1MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004089293-A2 | HYDROXAMIC ACID COMPOUNDS AND METHODS OF USE THEREOF | MEMORIAL SLOAN-KETTERING CANCER CENTER (US) | 2004-10-21 | — | — | WO | disclosed |