Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 17/20 | 0.51 |
| ▸ | PDE4A | P27815 | 1/20 | 0.51 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.51 |
| ▸ | CNR2 | P34972 | 2/20 | 0.46 |
| ▸ | HPGD | P15428 | 1/20 | 0.45 |
| ▸ | RAB9A | P51151 | 1/20 | 0.45 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.45 |
| ▸ | CNR1 | P21554 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839702 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4D | |
| SCHEMBL5839698 | 0.89 | PDE4B (0.50) | PDE4BPDE4APDE4D | |
| SCHEMBL5839215 | 0.89 | CNR1 (0.44) | PDE4BPDE4APDE4DCNR1 | |
| SCHEMBL5840163 | 0.89 | CNR1 (0.44) | PDE4BPDE4APDE4DCNR1 | |
| SCHEMBL5778513 | 0.88 | PTGER4 (0.43) | PDE4BPDE4APDE4D | |
| SCHEMBL5779293 | 0.87 | PDE4B (0.49) | PDE4BPDE4APDE4D | |
| SCHEMBL5779289 | 0.87 | PDE4B (0.49) | PDE4BPDE4APDE4D | |
| SCHEMBL5839350 | 0.87 | PDE4B (0.49) | PDE4BPDE4APDE4D | |
| SCHEMBL5841960 | 0.83 | PDE4B (0.53) | PDE4BPDE4APDE4D | |
| SCHEMBL5841951 | 0.83 | PDE4B (0.53) | PDE4BPDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009966-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |