Predicted protein targets (top 17)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTT | P42858 | 3/20 | 0.56 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.53 |
| ▸ | NAMPT | P43490 | 2/20 | 0.46 |
| ▸ | MEN1 | O00255 | 2/20 | 0.44 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.44 |
| ▸ | CNR1 | P21554 | 1/20 | 0.44 |
| ▸ | CNR2 | P34972 | 1/20 | 0.44 |
| ▸ | POLB | P06746 | 1/20 | 0.43 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.43 |
| ▸ | EPHX1 | P07099 | 2/20 | 0.42 |
| ▸ | LMNA | P02545 | 1/20 | 0.42 |
| ▸ | PKM | P14618 | 1/20 | 0.41 |
| ▸ | GAA | P10253 | 1/20 | 0.41 |
| ▸ | L3MBTL1 | Q9Y468 | 1/20 | 0.41 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.41 |
| ▸ | NPC1 | O15118 | 1/20 | 0.41 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318846 | 0.86 | HTT (0.54) | HTTTDP1NAMPTMEN1KMT2A | |
| SCHEMBL18663716 | 0.82 | HTT (0.43) | HTTTDP1NAMPTMEN1KMT2A | |
| SCHEMBL19189721 | 0.82 | HTT (0.43) | HTTTDP1NAMPTMEN1KMT2A | |
| SCHEMBL12800854 | 0.80 | KMT2A (0.61) | HTTMEN1KMT2APOLBMAPK1 | |
| SCHEMBL4732560 | 0.77 | HTT (0.69) | HTTTDP1NAMPTMEN1KMT2A | |
| SCHEMBL5802069 | 0.77 | HTT (0.69) | HTTTDP1NAMPTMEN1KMT2A | |
| SCHEMBL7090664 | 0.76 | HTT (0.54) | HTTTDP1NAMPTEPHX1 | |
| SCHEMBL7091820 | 0.76 | HTT (0.54) | HTTTDP1NAMPTEPHX1 | |
| SCHEMBL14105071 | 0.76 | HTT (0.58) | HTTTDP1NAMPTMEN1KMT2A | |
| SCHEMBL1627349 | 0.76 | HTT (0.43) | HTTTDP1NAMPTMEN1KMT2A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0874828-A4 | COMPOSITION FOR TREATING PAIN | LILLY CO ELI (US) | 1999-09-01 | — | — | EP | disclosed |
| EP-0874828-A1 | COMPOSITION FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1998-11-04 | — | — | EP | disclosed |
| WO-1997020819-A1 | COMPOSITION FOR TREATING PAIN | ELI LILLY AND COMPANY (US) | 1997-06-12 | — | — | WO | disclosed |