Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 16/20 | 0.59 |
| ▸ | CHUK | O15111 | 13/20 | 0.59 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.54 |
| ▸ | CDK2 | P24941 | 1/20 | 0.54 |
| ▸ | JAK2 | O60674 | 3/20 | 0.52 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.52 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.52 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.52 |
| ▸ | MAPK11 | Q15759 | 1/20 | 0.52 |
| ▸ | MAPK14 | Q16539 | 1/20 | 0.52 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.51 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.51 |
| ▸ | JAK1 | P23458 | 1/20 | 0.51 |
| ▸ | TYK2 | P29597 | 1/20 | 0.51 |
| ▸ | JAK3 | P52333 | 1/20 | 0.51 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.51 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.51 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.51 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312856 | 0.94 | IKBKB (0.57) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8312297 | 0.91 | IKBKB (0.64) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8313176 | 0.89 | IKBKB (0.58) | IKBKBCHUK | |
| SCHEMBL8312171 | 0.89 | IKBKB (0.54) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8308491 | 0.89 | IKBKB (0.57) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8309279 | 0.89 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8312299 | 0.87 | IKBKB (0.72) | IKBKBCHUK | |
| SCHEMBL8315439 | 0.87 | IKBKB (0.54) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8314752 | 0.87 | IKBKB (0.55) | IKBKBCHUKCCNE1CDK2JAK2 | |
| SCHEMBL8308557 | 0.87 | IKBKB (0.59) | IKBKBCHUKCCNE1CDK2JAK2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |