Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4B | Q07343 | 18/20 | 0.53 |
| ▸ | PDE4A | P27815 | 1/20 | 0.53 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.53 |
| ▸ | F2 | P00734 | 1/20 | 0.41 |
| ▸ | F10 | P00742 | 1/20 | 0.41 |
| ▸ | PRSS1 | P07477 | 1/20 | 0.41 |
| ▸ | PRSS2 | P07478 | 1/20 | 0.41 |
| ▸ | PRSS3 | P35030 | 1/20 | 0.41 |
| ▸ | ST14 | Q9Y5Y6 | 1/20 | 0.41 |
| ▸ | SMYD3 | Q9H7B4 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5424886 | 1.00 | PDE4B (0.53) | PDE4BPDE4APDE4DF2F10 | |
| SCHEMBL5441686 | 0.93 | PDE4B (0.53) | PDE4BPDE4APDE4DF2F10 | |
| SCHEMBL5424882 | 0.91 | PDE4B (0.51) | PDE4BPDE4APDE4D | |
| SCHEMBL5433091 | 0.90 | PDE4B (0.62) | PDE4BPDE4APDE4D | |
| SCHEMBL5426448 | 0.89 | PDE4B (0.55) | PDE4BPDE4APDE4D | |
| SCHEMBL5430829 | 0.87 | PDE4B (0.60) | PDE4BPDE4APDE4D | |
| SCHEMBL5432109 | 0.87 | PDE4B (0.55) | PDE4BPDE4APDE4D | |
| SCHEMBL14562583 | 0.87 | PDE4B (0.51) | PDE4BPDE4APDE4D | |
| SCHEMBL6056204 | 0.87 | PDE4B (0.51) | PDE4BPDE4APDE4D | |
| SCHEMBL5427210 | 0.87 | PDE4B (0.73) | PDE4BPDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20070066645-A1 | NOVEL COMPOUNDS | PFIZER INC. | 2007-03-22 | — | — | US | disclosed |
| US-20070066645-A1 | NOVEL COMPOUNDS | PFIZER INC. | 2007-03-22 | — | — | US | disclosed |
| WO-2005009438-A1 | NICOTINAMIDE COMPOUNDS USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20070066645-A1 | NOVEL COMPOUNDS | NQO1, NAMPT, NADK | PDE4B 712/4885PDE4A 1010/4885PDE4D 902/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.