Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | JAK2 | O60674 | 17/20 | 0.82 |
| ▸ | MAPK8 | P45983 | 3/20 | 0.66 |
| ▸ | MAPK10 | P53779 | 2/20 | 0.66 |
| ▸ | JAK3 | P52333 | 8/20 | 0.65 |
| ▸ | HDAC1 | Q13547 | 3/20 | 0.65 |
| ▸ | JAK1 | P23458 | 3/20 | 0.65 |
| ▸ | TYK2 | P29597 | 3/20 | 0.65 |
| ▸ | HDAC6 | Q9UBN7 | 2/20 | 0.65 |
| ▸ | HDAC3 | O15379 | 1/20 | 0.65 |
| ▸ | NCOR1 | O75376 | 1/20 | 0.65 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.65 |
| ▸ | HDAC8 | Q9BY41 | 1/20 | 0.65 |
| ▸ | IKBKB | O14920 | 1/20 | 0.61 |
| ▸ | CHUK | O15111 | 1/20 | 0.61 |
| ▸ | BMPR1B | O00238 | 1/20 | 0.58 |
| ▸ | PLK4 | O00444 | 1/20 | 0.58 |
| ▸ | CIT | O14578 | 1/20 | 0.58 |
| ▸ | GAK | O14976 | 1/20 | 0.58 |
| ▸ | OPA1 | O60313 | 1/20 | 0.58 |
| ▸ | ROCK2 | O75116 | 1/20 | 0.58 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13590716 | 0.90 | JAK2 (1.00) | JAK2MAPK8MAPK10JAK3HDAC1 | |
| SCHEMBL2875288 | 0.90 | JAK2 (1.00) | JAK2MAPK8MAPK10JAK3HDAC1 | |
| Hydrochloric Acid SCHEMBL30221695 | 0.89 | JAK2 (0.96) | JAK2MAPK8MAPK10JAK3HDAC1 | |
| SCHEMBL4385532 | 0.85 | JAK2 (1.00) | JAK2MAPK8JAK3HDAC1JAK1 | |
| SCHEMBL4381056 | 0.85 | JAK2 (1.00) | JAK2MAPK8JAK3HDAC1JAK1 | |
| SCHEMBL8236878 | 0.84 | JAK2 (0.66) | JAK2MAPK8MAPK10JAK3HDAC1 | |
| SCHEMBL4376882 | 0.83 | JAK2 (0.98) | JAK2MAPK8JAK3HDAC1JAK1 | |
| SCHEMBL3518338 | 0.83 | JAK2 (0.82) | JAK2MAPK8MAPK10JAK3HDAC1 | |
| SCHEMBL4800404 | 0.81 | MAPK8 (0.83) | JAK2MAPK8MAPK10JAK3IKBKB | |
| SCHEMBL8236707 | 0.81 | JAK2 (0.78) | JAK2MAPK8JAK3HDAC1JAK1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7442699-B2 | Anilinopyrimidine derivatives as IKK inhibitors and compositions and methods related thereto | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-10-28 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |