Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | KIT | P10721 | 3/20 | 0.53 |
| ▸ | TNIK | Q9UKE5 | 4/20 | 0.51 |
| ▸ | AXL | P30530 | 4/20 | 0.51 |
| ▸ | CDK8 | P49336 | 1/20 | 0.51 |
| ▸ | SGK1 | O00141 | 5/20 | 0.49 |
| ▸ | ALK | Q9UM73 | 2/20 | 0.49 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.47 |
| ▸ | PIK3CA | P42336 | 1/20 | 0.47 |
| ▸ | NEK1 | Q96PY6 | 1/20 | 0.47 |
| ▸ | CAMKK2 | Q96RR4 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL12829942 | 0.87 | NTRK1 (0.56) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL8320062 | 0.87 | AXL (0.54) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL8320397 | 0.84 | KIT (0.57) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL8320017 | 0.84 | MAPK8 (0.57) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL8314585 | 0.82 | MAP3K11 (0.64) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL8313449 | 0.81 | MAP4K1 (0.58) | TNIKAXLCDK8SGK1ALK | |
| SCHEMBL8445000 | 0.80 | ALK (0.46) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL4402102 | 0.80 | JAK2 (0.63) | TNIKAXLCDK8SGK1ALK | |
| SCHEMBL8445630 | 0.80 | NTRK1 (0.48) | KITTNIKAXLCDK8SGK1 | |
| SCHEMBL8488878 | 0.80 | AXL (0.46) | TNIKAXLCDK8SGK1ALK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2295433-A2 | JNK inhibitors | Eisai R&D Management Co., Ltd. (JP) | 2011-03-16 | — | — | EP | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |