SCHEMBL8313829

SCHEMBL8313829

Cc1ccc(C(=O)Nc2ccc(C(=O)N3Cc4cccn4Cc4ccoc43)cc2)c(C)c1

nearest known ligand 0.61

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 5/20 0.56
AVPR1A P37288 5/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8315651 0.92 AVPR2 (0.61) AVPR2AVPR1A
SCHEMBL8314301 0.91 AVPR2 (0.62) AVPR2AVPR1A
SCHEMBL7337827 0.91 AVPR2 (0.59) AVPR2AVPR1A
SCHEMBL8313184 0.89 AVPR2 (0.54) AVPR2AVPR1A
SCHEMBL8315353 0.88 AVPR2 (0.56) AVPR2AVPR1A
SCHEMBL8317065 0.87 AVPR2 (0.51) AVPR2AVPR1A
SCHEMBL8316129 0.86 AVPR2 (0.51) AVPR2AVPR1A
SCHEMBL8316086 0.85 AVPR2 (0.53) AVPR2AVPR1A
SCHEMBL8314334 0.85 AVPR2 (0.73) AVPR2AVPR1A
SCHEMBL8316318 0.84 AVPR2 (0.64) AVPR2AVPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0772615-B1 IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME RHONE POULENC RORER SA (FR) 1999-09-22 EP disclosed
EP-0636625-B1 Tricyclic diazepines vasopressin and oxytocin antagonists AMERICAN CYANAMID CO (US) 1999-01-27 EP disclosed
EP-0772615-A1 IMIDAZO 1,2-a]INDENO 1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME Aventis Pharma S.A. (FR) 1997-05-14 EP disclosed
WO-1996002544-A1 IMIDAZO[1,2-a]INDENO[1,2-e]PYRAZINE-2-CARBOXYLIC ACID DERIVATIVES, PREPARATION THEREOF AND DRUGS CONTAINING SAME RHONE-POULENC RORER S.A. (FR) 1996-02-01 WO disclosed