Predicted protein targets (top 6)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | IKBKB | O14920 | 17/20 | 0.63 |
| ▸ | CHUK | O15111 | 16/20 | 0.63 |
| ▸ | JAK2 | O60674 | 2/20 | 0.54 |
| ▸ | JAK3 | P52333 | 2/20 | 0.54 |
| ▸ | MTOR | P42345 | 1/20 | 0.51 |
| ▸ | SMG1 | Q96Q15 | 1/20 | 0.51 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL14063888 | 0.93 | IKBKB (0.63) | IKBKBCHUK | |
| SCHEMBL8308545 | 0.93 | IKBKB (0.69) | IKBKBCHUKMTORSMG1 | |
| SCHEMBL8311423 | 0.91 | IKBKB (0.67) | IKBKBCHUKMTORSMG1 | |
| SCHEMBL8308729 | 0.91 | IKBKB (0.61) | IKBKBCHUKMTORSMG1 | |
| SCHEMBL8312614 | 0.91 | IKBKB (0.66) | IKBKBCHUKJAK2MTORSMG1 | |
| SCHEMBL8311421 | 0.91 | IKBKB (0.66) | IKBKBCHUKJAK2MTORSMG1 | |
| SCHEMBL8312528 | 0.90 | IKBKB (0.57) | IKBKBCHUKJAK2JAK3MTOR | |
| SCHEMBL8309612 | 0.90 | IKBKB (0.71) | IKBKBCHUK | |
| SCHEMBL8308666 | 0.90 | IKBKB (0.65) | IKBKBCHUKJAK2 | |
| SCHEMBL8311631 | 0.90 | IKBKB (0.59) | IKBKBCHUKMTORSMG1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-1349841-B1 | ANILINOPYRIMIDINE DERIVATIVES AS IKK INHIBITORS AND COMPOSITIONS AND METHODS RELATED THERETO | SIGNAL PHARM LLC (US) | 2009-12-02 | — | — | EP | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| US-7429599-B2 | Methods for treating or preventing an inflammatory or metabolic condition or inhibiting JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2008-09-30 | — | — | US | disclosed |
| WO-2004084901-A1 | METHODS FOR TREATING OR PREVENTING AN INFLAMMATORY OR METABOLIC CONDITION BY INHIBITING JNK | SIGNAL PHARMACEUTICALS, LLC (US) | 2004-10-07 | — | — | WO | disclosed |