⚠ Novel chemotype — no close known analogue (best Tanimoto < 0.3). Unexplored chemical space relative to ChEMBL.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5662995 | 0.79 | CYP2D6 (0.35) | — | |
| SCHEMBL4209389 | 0.75 | — | — | |
| SCHEMBL6178735 | 0.75 | TDP1 (0.32) | — | |
| SCHEMBL4502028 | 0.74 | TDP1 (0.33) | — | |
| SCHEMBL3196903 | 0.73 | TDP1 (0.31) | — | |
| SCHEMBL937940 | 0.73 | TDP1 (0.31) | — | |
| SCHEMBL3327598 | 0.73 | TDP1 (0.31) | — | |
| SCHEMBL292628 | 0.71 | TDP1 (0.31) | — | |
| SCHEMBL3982585 | 0.71 | — | — | |
| SCHEMBL567668 | 0.70 | TDP1 (0.31) | — |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 4 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0662481-B1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO INC (US) | 1999-03-24 | — | — | EP | disclosed |
| US-5578593-A | RELEASING GROWTH HORMONES FOR ANIMALS | MERCK & CO., INC. (US) | 1996-11-26 | — | — | US | disclosed |
| EP-0662481-A1 | Spiro piperidines and homologs promote release of growth hormone | MERCK & CO. INC. (US) | 1995-07-12 | — | — | EP | disclosed |
| WO-1994019367-A1 | SPIRO PIPERIDINES AND HOMOLOGS PROMOTE RELEASE OF GROWTH HORMONE | MERCK & CO., INC. (US) | 1994-09-01 | — | — | WO | disclosed |