Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CDK8 | P49336 | 3/20 | 0.73 |
| ▸ | CDK2 | P24941 | 4/20 | 0.58 |
| ▸ | CCNT1 | O60563 | 2/20 | 0.58 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.58 |
| ▸ | CDK9 | P50750 | 2/20 | 0.58 |
| ▸ | AXL | P30530 | 5/20 | 0.52 |
| ▸ | TNIK | Q9UKE5 | 1/20 | 0.52 |
| ▸ | IGF1R | P08069 | 2/20 | 0.47 |
| ▸ | IMPDH2 | P12268 | 1/20 | 0.47 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.45 |
| ▸ | PLK4 | O00444 | 2/20 | 0.45 |
| ▸ | AURKA | O14965 | 2/20 | 0.45 |
| ▸ | ROCK2 | O75116 | 2/20 | 0.45 |
| ▸ | PRKD3 | O94806 | 2/20 | 0.45 |
| ▸ | INSR | P06213 | 2/20 | 0.45 |
| ▸ | CDK1 | P06493 | 2/20 | 0.45 |
| ▸ | FES | P07332 | 2/20 | 0.45 |
| ▸ | ROS1 | P08922 | 2/20 | 0.45 |
| ▸ | FGFR1 | P11362 | 2/20 | 0.45 |
| ▸ | PHKG2 | P15735 | 2/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL13745464 | 0.85 | CDK8 (1.00) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL8320115 | 0.84 | CDK8 (0.84) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL8313417 | 0.83 | CDK8 (0.73) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL8324861 | 0.82 | CDK8 (0.85) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL12763457 | 0.81 | CDK8 (0.79) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL13745492 | 0.81 | CDK8 (0.73) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL8324926 | 0.81 | CDK8 (0.73) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL8314540 | 0.81 | CDK8 (0.73) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL8320981 | 0.81 | CDK8 (0.73) | CDK8CDK2CCNT1CCNA2CDK9 | |
| SCHEMBL12763453 | 0.81 | CDK8 (0.77) | CDK8CDK2CCNT1CCNA2CDK9 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-20090215771-A1 | JNK INHIBITORS | GRACZYK PIOTR | 2009-08-27 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| US-7432375-B2 | JNK inhibitors | EISAI R & D MANAGEMENT CO., LTD. (JP) | 2008-10-07 | — | — | US | disclosed |
| WO-2004078756-A2 | JNK INHIBITORS | EISAI CO., LTD. (JP) | 2004-09-16 | — | — | WO | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20090215771-A1 | JNK INHIBITORS | MAPKAPK2, MAPK1, MAPKAPK3 | CDK8 360/4885CDK2 153/4885CCNT1 1186/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.