Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PDE4A | P27815 | 11/20 | 0.48 |
| ▸ | PDE4B | Q07343 | 11/20 | 0.48 |
| ▸ | PDE4C | Q08493 | 11/20 | 0.48 |
| ▸ | PDE4D | Q08499 | 11/20 | 0.48 |
| ▸ | CYP1A2 | P05177 | 2/20 | 0.43 |
| ▸ | CYP1A1 | P04798 | 1/20 | 0.43 |
| ▸ | CYP1B1 | Q16678 | 1/20 | 0.43 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.42 |
| ▸ | CYP2C9 | P11712 | 1/20 | 0.42 |
| ▸ | TSHR | P16473 | 1/20 | 0.42 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.42 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.42 |
| ▸ | CES2 | O00748 | 1/20 | 0.42 |
| ▸ | CES1 | P23141 | 1/20 | 0.42 |
| ▸ | CA12 | O43570 | 1/20 | 0.41 |
| ▸ | CA1 | P00915 | 1/20 | 0.41 |
| ▸ | CA2 | P00918 | 1/20 | 0.41 |
| ▸ | CA4 | P22748 | 1/20 | 0.41 |
| ▸ | CA6 | P23280 | 1/20 | 0.41 |
| ▸ | CA7 | P43166 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8269867 | 0.89 | MEN1 (0.45) | MAOBMEN1KMT2A | |
| SCHEMBL13984813 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL13986023 | 0.82 | PDE4A (0.69) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL5191943 | 0.82 | CA12 (0.49) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8319883 | 0.80 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL11764286 | 0.78 | CYP1A2 (0.64) | CYP1A2CYP3A4CYP2C9TSHRCYP2C19 | |
| SCHEMBL8320626 | 0.78 | PDE4A (0.48) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8269329 | 0.77 | PDE4A (0.70) | PDE4APDE4BPDE4CPDE4D | |
| SCHEMBL8320190 | 0.74 | PDE4A (0.62) | PDE4APDE4BPDE4CPDE4DCYP1A2 | |
| SCHEMBL8269338 | 0.74 | PDE4A (0.66) | PDE4APDE4BPDE4CPDE4DCA12 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2004078144-A2 | DIPHENYLETHYLENE COMPOUNDS AND USES THEREOF | CELGENE CORPORATION (US) | 2004-09-16 | — | — | WO | disclosed |