Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | GSK3B | P49841 | 18/20 | 0.76 |
| ▸ | CYP2D6 | P10635 | 12/20 | 0.76 |
| ▸ | CYP1A2 | P05177 | 8/20 | 0.76 |
| ▸ | CSNK1A1 | P48729 | 1/20 | 0.56 |
| ▸ | GSK3A | P49840 | 1/20 | 0.56 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL83142 | 1.00 | GSK3B (0.76) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL2115218 | 0.95 | GSK3B (0.69) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL2114762 | 0.95 | GSK3B (0.69) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL2114764 | 0.95 | GSK3B (0.69) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL538080 | 0.93 | GSK3B (0.65) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL12330430 | 0.92 | GSK3B (0.64) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL2118012 | 0.88 | GSK3B (0.58) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL83125 | 0.88 | GSK3B (0.76) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL83126 | 0.88 | GSK3B (0.76) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A | |
| SCHEMBL12003453 | 0.88 | GSK3B (0.58) | GSK3BCYP2D6CYP1A2CSNK1A1GSK3A |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-8129377-B2 | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | claimed |
| US-8129377-B2 | 6-(pyridinyl)-4-pyrimidone derivates as tau protein kinase 1 inhibitors | MITSUBISHI TANABE PHARMA CORPORATION (JP) | 2012-03-06 | — | — | US | disclosed |