Predicted protein targets (top 18)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 5/20 | 0.57 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.57 |
| ▸ | HPGD | P15428 | 1/20 | 0.57 |
| ▸ | HTT | P42858 | 1/20 | 0.57 |
| ▸ | BTK | Q06187 | 1/20 | 0.49 |
| ▸ | SYK | P43405 | 4/20 | 0.49 |
| ▸ | EPHA2 | P29317 | 2/20 | 0.46 |
| ▸ | KDR | P35968 | 2/20 | 0.46 |
| ▸ | EPHB4 | P54760 | 1/20 | 0.46 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.45 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.44 |
| ▸ | CDK2 | P24941 | 1/20 | 0.44 |
| ▸ | MAPK8 | P45983 | 1/20 | 0.44 |
| ▸ | MAPK9 | P45984 | 1/20 | 0.44 |
| ▸ | MAPK10 | P53779 | 1/20 | 0.44 |
| ▸ | BRAF | P15056 | 3/20 | 0.44 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.43 |
| ▸ | PAK1 | Q13153 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314679 | 1.00 | EGFR (0.57) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL6994172 | 0.93 | EGFR (0.69) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL6994175 | 0.93 | EGFR (0.69) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL8318921 | 0.93 | EGFR (0.60) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL8318924 | 0.93 | EGFR (0.60) | EGFRERBB2HPGDHTTSYK | |
| SCHEMBL6997256 | 0.90 | EGFR (0.51) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL6997260 | 0.90 | EGFR (0.51) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL8457936 | 0.89 | EGFR (0.53) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL8457941 | 0.89 | EGFR (0.53) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL6999193 | 0.89 | EGFR (0.65) | EGFRERBB2HPGDHTTSYK |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |