Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.61 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.61 |
| ▸ | HTT | P42858 | 2/20 | 0.61 |
| ▸ | HPGD | P15428 | 1/20 | 0.61 |
| ▸ | SYK | P43405 | 1/20 | 0.59 |
| ▸ | PKMYT1 | Q99640 | 1/20 | 0.55 |
| ▸ | AURKA | O14965 | 1/20 | 0.55 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 2/20 | 0.53 |
| ▸ | BRD4 | O60885 | 2/20 | 0.52 |
| ▸ | NTRK1 | P04629 | 2/20 | 0.51 |
| ▸ | CDK2 | P24941 | 2/20 | 0.48 |
| ▸ | CDK9 | P50750 | 2/20 | 0.48 |
| ▸ | CCNK | O75909 | 1/20 | 0.48 |
| ▸ | CCNA2 | P20248 | 1/20 | 0.48 |
| ▸ | CCND3 | P30281 | 1/20 | 0.48 |
| ▸ | CDK6 | Q00534 | 1/20 | 0.48 |
| ▸ | CCNT1 | O60563 | 1/20 | 0.48 |
| ▸ | CCNE1 | P24864 | 1/20 | 0.48 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798694 | 0.93 | EGFR (0.63) | EGFRERBB2HTTHPGDSYK | |
| SCHEMBL8489312 | 0.87 | EGFR (0.63) | EGFRERBB2HTTHPGDMAPT | |
| SCHEMBL8317992 | 0.87 | EGFR (0.68) | EGFRERBB2HTTHPGDMAPT | |
| SCHEMBL8488002 | 0.86 | LRRK2 (0.57) | EGFRERBB2HTTHPGDMAPT | |
| SCHEMBL8483701 | 0.84 | EGFR (0.55) | EGFRERBB2HTTHPGDSYK | |
| SCHEMBL8488618 | 0.84 | EGFR (0.60) | EGFRERBB2HTTHPGDSYK | |
| SCHEMBL8317682 | 0.83 | EGFR (0.70) | EGFRERBB2HTTHPGDMAPT | |
| SCHEMBL8314171 | 0.82 | EGFR (0.58) | EGFRERBB2HTTHPGDMAPT | |
| SCHEMBL8319353 | 0.81 | EGFR (0.61) | EGFRERBB2HTTHPGDMAPT | |
| SCHEMBL6997201 | 0.81 | EGFR (0.71) | EGFRERBB2HTTHPGDMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |