Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.51 |
| ▸ | HPGD | P15428 | 1/20 | 0.51 |
| ▸ | HTT | P42858 | 1/20 | 0.51 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | DYRK1A | Q13627 | 1/20 | 0.46 |
| ▸ | MEN1 | O00255 | 1/20 | 0.46 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.46 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.46 |
| ▸ | AURKA | O14965 | 1/20 | 0.45 |
| ▸ | RPS6KB1 | P23443 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315340 | 1.00 | EGFR (0.51) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8314173 | 0.92 | EGFR (0.52) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8314168 | 0.92 | EGFR (0.52) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8318043 | 0.91 | EGFR (0.53) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8318047 | 0.91 | EGFR (0.53) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315095 | 0.90 | EGFR (0.52) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315100 | 0.90 | EGFR (0.52) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315928 | 0.89 | EGFR (0.51) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8315926 | 0.89 | EGFR (0.51) | EGFRERBB2HPGDHTTGRM1 | |
| SCHEMBL8319249 | 0.88 | EGFR (0.55) | EGFRERBB2HPGDHTTGRM1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |