Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 10/20 | 0.64 |
| ▸ | ERBB2 | P04626 | 4/20 | 0.64 |
| ▸ | MAPT | P10636 | 1/20 | 0.64 |
| ▸ | HPGD | P15428 | 1/20 | 0.62 |
| ▸ | HTT | P42858 | 1/20 | 0.62 |
| ▸ | BRAF | P15056 | 9/20 | 0.47 |
| ▸ | MEN1 | O00255 | 1/20 | 0.42 |
| ▸ | KMT2A | Q03164 | 1/20 | 0.42 |
| ▸ | ERBB4 | Q15303 | 1/20 | 0.42 |
| ▸ | GRM1 | Q13255 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314031 | 0.95 | EGFR (0.60) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998075 | 0.89 | EGFR (0.69) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317671 | 0.87 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6992399 | 0.87 | EGFR (0.71) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8316771 | 0.87 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8487889 | 0.86 | EGFR (0.70) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8313724 | 0.85 | EGFR (0.63) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6990205 | 0.85 | EGFR (0.74) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8316668 | 0.85 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8319143 | 0.85 | EGFR (0.64) | EGFRERBB2MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |