Predicted protein targets (top 16)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 9/20 | 0.62 |
| ▸ | BRAF | P15056 | 2/20 | 0.51 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.50 |
| ▸ | HPGD | P15428 | 1/20 | 0.50 |
| ▸ | HTT | P42858 | 1/20 | 0.50 |
| ▸ | SYK | P43405 | 8/20 | 0.49 |
| ▸ | KCNH2 | Q12809 | 7/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 5/20 | 0.49 |
| ▸ | MAPK1 | P28482 | 5/20 | 0.49 |
| ▸ | AURKB | Q96GD4 | 5/20 | 0.49 |
| ▸ | GP6 | Q9HCN6 | 1/20 | 0.45 |
| ▸ | ADRA2A | P08913 | 1/20 | 0.45 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.45 |
| ▸ | HRH1 | P35367 | 1/20 | 0.45 |
| ▸ | HTR2B | P41595 | 1/20 | 0.45 |
| ▸ | MCHR1 | Q99705 | 1/20 | 0.45 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315704 | 1.00 | EGFR (0.62) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8319428 | 0.91 | EGFR (0.73) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8318671 | 0.90 | CSNK2A1 (0.56) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8318663 | 0.90 | CSNK2A1 (0.56) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8318254 | 0.90 | EGFR (0.63) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8318278 | 0.90 | EGFR (0.63) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8318922 | 0.89 | EGFR (0.62) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8318928 | 0.89 | EGFR (0.62) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8319108 | 0.89 | EGFR (0.67) | EGFRBRAFERBB2HPGDHTT | |
| SCHEMBL8319114 | 0.89 | EGFR (0.67) | EGFRBRAFERBB2HPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |