Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | PTGER4 | P35408 | 2/20 | 0.37 |
| ▸ | UGCG | Q16739 | 1/20 | 0.36 |
| ▸ | PDE4B | Q07343 | 10/20 | 0.36 |
| ▸ | CCR8 | P51685 | 1/20 | 0.35 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.33 |
| ▸ | PDE4A | P27815 | 1/20 | 0.33 |
| ▸ | PDE4D | Q08499 | 1/20 | 0.33 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL5839602 | 0.87 | PDE4B (0.48) | PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL5839609 | 0.87 | PDE4B (0.48) | PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL8314996 | 0.84 | PTGER4 (0.39) | PTGER4PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL8315913 | 0.78 | PDE4B (0.41) | PTGER4PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL8297693 | 0.78 | PTGER4 (0.45) | PTGER4PDE4BPDE4APDE4D | |
| SCHEMBL5693434 | 0.75 | PTGER4 (0.52) | PTGER4PDE4BPDE4APDE4D | |
| SCHEMBL5776945 | 0.74 | PDE4B (0.51) | PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL5776940 | 0.74 | PDE4B (0.51) | PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL5842096 | 0.74 | PDE4B (0.51) | PDE4BCYP3A4PDE4APDE4D | |
| SCHEMBL5839644 | 0.73 | PDE4B (0.54) | PTGER4PDE4BCYP3A4PDE4APDE4D |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| WO-2005009966-A1 | NICOTINAMIDE DERIVATIVES USEFUL AS PDE4 INHIBITORS | PFIZER LIMITED (GB) | 2005-02-03 | — | — | WO | disclosed |