Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.60 |
| ▸ | SYK | P43405 | 2/20 | 0.42 |
| ▸ | KCNH2 | Q12809 | 2/20 | 0.42 |
| ▸ | MAPK3 | P27361 | 1/20 | 0.42 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.42 |
| ▸ | AURKB | Q96GD4 | 1/20 | 0.42 |
| ▸ | KHK | P50053 | 1/20 | 0.42 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8314185 | 0.84 | EGFR (0.63) | EGFRSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL8317556 | 0.83 | EGFR (0.67) | EGFRSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL8314443 | 0.82 | EGFR (0.60) | EGFR | |
| SCHEMBL8318090 | 0.80 | EGFR (0.77) | EGFR | |
| SCHEMBL8315088 | 0.79 | EGFR (0.62) | EGFR | |
| SCHEMBL8316963 | 0.78 | EGFR (0.86) | EGFRMAPK1 | |
| SCHEMBL8317938 | 0.78 | EGFR (0.73) | EGFR | |
| SCHEMBL8319428 | 0.78 | EGFR (0.73) | EGFRSYKKCNH2MAPK3MAPK1 | |
| SCHEMBL8320643 | 0.77 | EGFR (0.72) | EGFRSYKKCNH2AURKB | |
| SCHEMBL8314771 | 0.77 | EGFR (0.72) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |