Predicted protein targets (top 3)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | AVPR1A | P37288 | 11/20 | 0.73 |
| ▸ | AVPR2 | P30518 | 9/20 | 0.73 |
| ▸ | OXTR | P30559 | 1/20 | 0.53 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317076 | 0.93 | AVPR2 (0.77) | AVPR1AAVPR2 | |
| SCHEMBL8319275 | 0.88 | AVPR2 (0.85) | AVPR1AAVPR2OXTR | |
| SCHEMBL8318033 | 0.87 | AVPR1A (0.69) | AVPR1AAVPR2 | |
| SCHEMBL8316581 | 0.85 | AVPR2 (0.71) | AVPR1AAVPR2 | |
| SCHEMBL8313791 | 0.85 | AVPR2 (0.83) | AVPR1AAVPR2 | |
| SCHEMBL5740017 | 0.85 | AVPR2 (0.73) | AVPR1AAVPR2 | |
| SCHEMBL8315535 | 0.85 | AVPR2 (1.00) | AVPR1AAVPR2 | |
| SCHEMBL8315264 | 0.83 | AVPR2 (0.75) | AVPR1AAVPR2 | |
| SCHEMBL5740726 | 0.83 | AVPR2 (0.70) | AVPR1AAVPR2 | |
| SCHEMBL8314926 | 0.83 | AVPR1A (0.68) | AVPR1AAVPR2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0630887-B1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LTD (GB) | 1999-07-28 | — | — | EP | disclosed |
| US-5654299-A | TREATING RESPIRATORY SYSTEM DISORDER (I.E. ASTHMA) WITH NEUROKININ 2 RECEPTOR ANTAGONIST | ZENECA LIMITED (GB) | 1997-08-05 | — | — | US | disclosed |
| EP-0630887-A1 | 4-(aryl-substituted)-piperidines as neurokinin receptor antagonists | ZENECA LIMITED (GB) | 1994-12-28 | — | — | EP | disclosed |