Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 20/20 | 0.62 |
| ▸ | ERBB2 | P04626 | 10/20 | 0.62 |
| ▸ | MAPT | P10636 | 2/20 | 0.62 |
| ▸ | HPGD | P15428 | 1/20 | 0.52 |
| ▸ | HTT | P42858 | 1/20 | 0.52 |
| ▸ | ERBB4 | Q15303 | 4/20 | 0.52 |
| ▸ | KIT | P10721 | 3/20 | 0.52 |
| ▸ | SRC | P12931 | 3/20 | 0.52 |
| ▸ | ERBB3 | P21860 | 3/20 | 0.52 |
| ▸ | CIT | O14578 | 2/20 | 0.52 |
| ▸ | GAK | O14976 | 2/20 | 0.52 |
| ▸ | EPHB6 | O15197 | 2/20 | 0.52 |
| ▸ | RIPK2 | O43353 | 2/20 | 0.52 |
| ▸ | STK17B | O94768 | 2/20 | 0.52 |
| ▸ | STK10 | O94804 | 2/20 | 0.52 |
| ▸ | ABL1 | P00519 | 2/20 | 0.52 |
| ▸ | LCK | P06239 | 2/20 | 0.52 |
| ▸ | LYN | P07948 | 2/20 | 0.52 |
| ▸ | RET | P07949 | 2/20 | 0.52 |
| ▸ | MET | P08581 | 2/20 | 0.52 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6999303 | 0.87 | EGFR (0.71) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6989118 | 0.86 | EGFR (0.60) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317992 | 0.85 | EGFR (0.68) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317856 | 0.85 | EGFR (0.63) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998708 | 0.84 | EGFR (0.67) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317480 | 0.83 | EGFR (0.66) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6996816 | 0.83 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6998959 | 0.83 | EGFR (0.66) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6994666 | 0.82 | EGFR (0.65) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6997124 | 0.81 | EGFR (0.66) | EGFRERBB2MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |