Predicted protein targets (top 14)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CYP2C8 | P10632 | 1/20 | 0.56 |
| ▸ | SCN9A | Q15858 | 5/20 | 0.35 |
| ▸ | SCN5A | Q14524 | 4/20 | 0.35 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.34 |
| ▸ | CRHR1 | P34998 | 1/20 | 0.34 |
| ▸ | PPARG | P37231 | 6/20 | 0.33 |
| ▸ | SCN2B | O60939 | 1/20 | 0.32 |
| ▸ | SCN1A | P35498 | 1/20 | 0.32 |
| ▸ | SCN1B | Q07699 | 1/20 | 0.32 |
| ▸ | PTGER4 | P35408 | 1/20 | 0.32 |
| ▸ | S1PR1 | P21453 | 1/20 | 0.32 |
| ▸ | FAAH | O00519 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | RCE1 | Q9Y256 | 1/20 | 0.32 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL831987 | 0.90 | CYP2C8 (0.60) | CYP2C8SCN9ASCN5AKMT2APPARG | |
| SCHEMBL832872 | 0.90 | CYP2C8 (0.60) | CYP2C8SCN9ASCN5AKMT2ASCN2B | |
| SCHEMBL831122 | 0.90 | CYP2C8 (0.59) | CYP2C8SCN9AKMT2ASCN2BSCN1A | |
| SCHEMBL831547 | 0.89 | CYP2C8 (0.56) | CYP2C8KMT2APTGER4FAAHALDH1A1 | |
| SCHEMBL831646 | 0.87 | CYP2C8 (0.74) | CYP2C8SCN9ASCN5AKMT2ASCN2B | |
| SCHEMBL862278 | 0.87 | CYP2C8 (0.64) | CYP2C8SCN9ASCN5AKMT2ASCN1A | |
| SCHEMBL831050 | 0.87 | SCN9A (0.41) | CYP2C8SCN9ASCN5AKMT2APPARG | |
| SCHEMBL831650 | 0.86 | CYP2C8 (0.65) | CYP2C8SCN9ASCN5AKMT2ASCN2B | |
| SCHEMBL12665637 | 0.86 | CYP2C8 (0.74) | CYP2C8KMT2AFAAHRCE1 | |
| SCHEMBL831412 | 0.85 | CYP2C8 (0.41) | CYP2C8SCN9ASCN5AKMT2APPARG |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-2197842-B1 | 2, 3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | SCHERING CORP (US) | 2012-05-23 | — | — | EP | disclosed |
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-8143305-B2 | 2,3-substituted indole derivatives for treating viral infections | SCHERING CORPORATION (US) | 2012-03-27 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | MERCK SHARP & DOHME CORP. | 2011-02-10 | — | — | US | disclosed |
Patent text — is the patent's own abstract consistent with the prediction?
For each of this compound's patents that has machine-readable text (1 of them — usually the abstract, not the full specification), we ask MedCPT which protein the text reads most about, and where the chemistry-predicted target lands among 4885 human targets. A high rank means the patent's own wording is consistent with the prediction — a weak, independent signal, not proof of activity.
| Patent | Title | Text reads most about | Predicted target · text-rank |
|---|---|---|---|
| US-20110033417-A1 | 2,3-SUBSTITUTED INDOLE DERIVATIVES FOR TREATING VIRAL INFECTIONS | IDO2, IDO1, IRF3 | CYP2C8 847/4885SCN9A 3807/4885SCN5A 1398/4885 |
“Text reads most about” is the patent abstract's nearest protein in MedCPT space (background-debiased). Only ~1.4% of patents have machine-readable text, so most compounds won't have this panel.