Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HMGCR | P04035 | 1/20 | 0.38 |
| ▸ | CHRM1 | P11229 | 1/20 | 0.38 |
| ▸ | TBXA2R | P21731 | 1/20 | 0.38 |
| ▸ | ADRA1A | P35348 | 1/20 | 0.38 |
| ▸ | TSHR | P16473 | 2/20 | 0.36 |
| ▸ | CYP2D6 | P10635 | 1/20 | 0.36 |
| ▸ | CYP2C19 | P33261 | 1/20 | 0.36 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.36 |
| ▸ | TET2 | Q6N021 | 1/20 | 0.34 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.32 |
| ▸ | FFAR1 | O14842 | 1/20 | 0.32 |
| ▸ | CPT2 | P23786 | 1/20 | 0.32 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.32 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.32 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | MAPT | P10636 | 1/20 | 0.31 |
| ▸ | HPGD | P15428 | 1/20 | 0.31 |
| ▸ | RAB9A | P51151 | 1/20 | 0.31 |
| ▸ | OR51E2 | Q9H255 | 1/20 | 0.30 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3697055 | 0.82 | HMGCR (0.41) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL8874275 | 0.80 | HMGCR (0.39) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL14914212 | 0.78 | HMGCR (0.40) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL4409454 | 0.72 | HMGCR (0.39) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL8675725 | 0.71 | HMGCR (0.41) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL8675721 | 0.71 | HMGCR (0.41) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL8677533 | 0.71 | HMGCR (0.41) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| T-Butylacetic Acid SCHEMBL27773562 | 0.71 | HMGCR (0.55) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL6857048 | 0.71 | CES1 (0.38) | HMGCRCHRM1TBXA2RADRA1ATSHR | |
| SCHEMBL27752720 | 0.71 | HMGCR (0.41) | HMGCRCHRM1TBXA2RADRA1ATSHR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0484881-B1 | Heteroaroyl derivatives of monocyclic beta-lactam antibiotics | SQUIBB & SONS INC (US) | 1999-04-07 | — | — | EP | disclosed |
| US-5705645-A | Hereroaryl derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1998-01-06 | — | — | US | disclosed |
| US-5420277-A | BACTERICIDE INTERMEDIATES | E. R. SQUIBB & SONS, INC. (US) | 1995-05-30 | — | — | US | disclosed |
| US-5290929-A | Heteroaryl derivatives of monocyclic beta-lactam antibiotics | E. R. SQUIBB & SONS, INC. (US) | 1994-03-01 | — | — | US | disclosed |
| EP-0484881-A2 | Heteroaroyl derivatives of monocyclic beta-lactam antibiotics | E.R. SQUIBB & SONS, INC. (US) | 1992-05-13 | — | — | EP | disclosed |