SCHEMBL8316505

SCHEMBL8316505

O=C(Nc1ccc(C(=O)N2Cc3ccc(Cl)n3Cc3ccccc32)cc1)c1ccccc1OC(F)(F)F

nearest known ligand 0.56

Predicted protein targets (top 2)

geneUniProtsupporting neighboursconfidence
AVPR2 P30518 3/20 0.54
AVPR1A P37288 3/20 0.54

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8314412 0.89 AVPR2 (0.54) AVPR2AVPR1A
SCHEMBL8318185 0.86 AVPR2 (0.59) AVPR2AVPR1A
SCHEMBL8317926 0.85 AVPR2 (0.61) AVPR2AVPR1A
SCHEMBL7333390 0.84 AVPR2 (0.62) AVPR2AVPR1A
SCHEMBL8317932 0.83 AVPR2 (0.50) AVPR2AVPR1A
SCHEMBL8558555 0.83 AVPR2 (0.55) AVPR2AVPR1A
SCHEMBL8318476 0.82 AVPR1A (0.54) AVPR2AVPR1A
SCHEMBL8316334 0.81 AVPR1A (0.54) AVPR2AVPR1A
SCHEMBL8316666 0.81 AVPR2 (0.59) AVPR2AVPR1A
SCHEMBL8316818 0.81 AVPR2 (0.53) AVPR2AVPR1A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0636625-B1 Tricyclic diazepines vasopressin and oxytocin antagonists AMERICAN CYANAMID CO (US) 1999-01-27 EP disclosed