Known targets — ChEMBL curated mechanism
The experimentally established mechanism targets of Vofopitant. The predicted profile below is derived independently by chemical similarity — agreement is a validation signal, a miss is honest.
Predicted protein targets (top 1)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | TACR1 known ✓ | P25103 | 19/20 | 1.00 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Vofopitant SCHEMBL5153521 | 1.00 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL310793 | 1.00 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL29711142 | 1.00 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL310338 | 0.99 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL7062769 | 0.99 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL8431760 | 0.99 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL30522777 | 0.99 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL8901341 | 0.99 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL2996010 | 0.99 | TACR1 (1.00) | TACR1 | |
| Vofopitant SCHEMBL30522778 | 0.99 | TACR1 (1.00) | TACR1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-5919803-A | TACHYKININ ANTAGONIST | GLAXO GROUP LIMITED (GB) | 1999-07-06 | — | — | US | disclosed |
| US-5843966-A | Piperidine derivatives | GLAXO GROUP LIMITED (GB) | 1998-12-01 | — | — | US | disclosed |
| US-5703240-A | ANALGESICS; ANTIINFLAMMATORY AGENTS; NERVOUS SYSTEM DISORDERS; PSYCHOLOGICAL DISORDERS; GASTROINTESTINAL DISORDERS | GLAXO GROUP LIMITED (GB) | 1997-12-30 | — | — | US | disclosed |