Predicted protein targets (top 8)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.51 |
| ▸ | EGFR | P00533 | 6/20 | 0.49 |
| ▸ | BRAF | P15056 | 11/20 | 0.47 |
| ▸ | TSHR | P16473 | 1/20 | 0.47 |
| ▸ | TP53 | P04637 | 1/20 | 0.47 |
| ▸ | RXFP1 | Q9HBX9 | 1/20 | 0.47 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
| ▸ | MAPT | P10636 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8799689 | 0.83 | EGFR (0.55) | EGFRBRAF | |
| SCHEMBL8316527 | 0.83 | EGFR (0.52) | EGFRBRAFERBB2MAPT | |
| SCHEMBL8314835 | 0.81 | EGFR (0.56) | EGFRBRAFERBB2MAPT | |
| SCHEMBL8313771 | 0.80 | EGFR (0.65) | EGFRBRAF | |
| SCHEMBL8320421 | 0.80 | EGFR (0.65) | EGFRBRAF | |
| SCHEMBL8315976 | 0.80 | EGFR (0.55) | ALDH1A1EGFRBRAFERBB2MAPT | |
| SCHEMBL8316302 | 0.80 | EGFR (0.59) | EGFRBRAFERBB2MAPT | |
| SCHEMBL8318909 | 0.80 | BRAF (0.53) | EGFRBRAF | |
| SCHEMBL8314169 | 0.79 | EGFR (0.64) | EGFRBRAF | |
| SCHEMBL8317540 | 0.79 | EGFR (0.57) | ALDH1A1EGFRBRAFERBB2MAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |