Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 7/20 | 0.56 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.56 |
| ▸ | MAPT | P10636 | 1/20 | 0.56 |
| ▸ | KHK | P50053 | 1/20 | 0.54 |
| ▸ | BRAF | P15056 | 12/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8316302 | 0.89 | EGFR (0.59) | EGFRERBB2MAPTKHKBRAF | |
| SCHEMBL8316527 | 0.89 | EGFR (0.52) | EGFRERBB2MAPTKHKBRAF | |
| SCHEMBL8317375 | 0.87 | EGFR (0.62) | EGFRERBB2MAPTKHKBRAF | |
| SCHEMBL8313771 | 0.86 | EGFR (0.65) | EGFRBRAF | |
| SCHEMBL8320421 | 0.86 | EGFR (0.65) | EGFRBRAF | |
| SCHEMBL8315976 | 0.86 | EGFR (0.55) | EGFRERBB2MAPTBRAF | |
| SCHEMBL8317028 | 0.85 | EGFR (0.61) | EGFRKHKBRAF | |
| SCHEMBL8317540 | 0.85 | EGFR (0.57) | EGFRERBB2MAPTBRAF | |
| SCHEMBL8314169 | 0.85 | EGFR (0.64) | EGFRBRAF | |
| SCHEMBL8316200 | 0.85 | EGFR (0.59) | EGFRBRAF |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |