Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 18/20 | 0.65 |
| ▸ | HTT | P42858 | 1/20 | 0.47 |
| ▸ | HIF1A | Q16665 | 1/20 | 0.47 |
| ▸ | MAPK1 | P28482 | 1/20 | 0.46 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8324295 | 0.92 | EGFR (0.63) | EGFRHTTHIF1AMAPK1 | |
| SCHEMBL8314278 | 0.86 | EGFR (0.61) | EGFRHTTHIF1AMAPK1ERBB2 | |
| SCHEMBL8319518 | 0.85 | EGFR (0.60) | EGFRMAPK1ERBB2 | |
| SCHEMBL8313771 | 0.83 | EGFR (0.65) | EGFRHTT | |
| SCHEMBL8320421 | 0.83 | EGFR (0.65) | EGFRHTT | |
| SCHEMBL8317375 | 0.82 | EGFR (0.62) | EGFRERBB2 | |
| SCHEMBL8315000 | 0.82 | EGFR (0.62) | EGFRHTTHIF1A | |
| SCHEMBL8315003 | 0.82 | EGFR (0.62) | EGFRHTTHIF1A | |
| SCHEMBL6997938 | 0.82 | EGFR (0.62) | EGFRHTTHIF1A | |
| SCHEMBL8316302 | 0.82 | EGFR (0.59) | EGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |