Predicted protein targets (top 12)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 5/20 | 0.57 |
| ▸ | ADRB2 | P07550 | 1/20 | 0.57 |
| ▸ | APP | P05067 | 5/20 | 0.56 |
| ▸ | HTR6 | P50406 | 2/20 | 0.48 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.48 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.48 |
| ▸ | MAPT | P10636 | 1/20 | 0.48 |
| ▸ | HTR4 | Q13639 | 1/20 | 0.47 |
| ▸ | HTR2A | P28223 | 2/20 | 0.47 |
| ▸ | HTR2B | P41595 | 1/20 | 0.47 |
| ▸ | MTNR1A | P48039 | 1/20 | 0.46 |
| ▸ | MTNR1B | P49286 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| Hydrochloric Acid SCHEMBL11841895 | 0.99 | HTR2C (0.58) | HTR2CADRB2APPHTR6KDM4E | |
| SCHEMBL2264043 | 0.89 | HTR2C (0.60) | HTR2CADRB2APPHTR6HTR4 | |
| Hydrochloric Acid SCHEMBL11847902 | 0.87 | HTR2C (0.59) | HTR2CADRB2APPHTR6KDM4E | |
| SCHEMBL4676883 | 0.81 | HTR2C (0.62) | HTR2CADRB2APPHTR2A | |
| SCHEMBL25079811 | 0.81 | HTR2C (0.58) | HTR2CADRB2APPHTR6MAPT | |
| SCHEMBL6358819 | 0.81 | HTR2C (0.58) | HTR2CADRB2APPHTR6MAPT | |
| SCHEMBL25079814 | 0.81 | HTR2C (0.58) | HTR2CADRB2APPHTR6MAPT | |
| SCHEMBL26776434 | 0.79 | HTR2A (0.46) | HTR2CAPPHTR6KDM4EALDH1A1 | |
| SCHEMBL26776464 | 0.79 | HTR2A (0.46) | HTR2CAPPHTR6KDM4EALDH1A1 | |
| SCHEMBL16801567 | 0.78 | HTR2C (0.56) | HTR2CADRB2APPKDM4EALDH1A1 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 8 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| US-3993764-A | 3-(4*-PIPERIDYL)-INDOLES | ROUSSEL-UCLAF (FR) | 1976-11-23 | — | — | US | claimed |
| EP-0536419-B1 | TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF | TORAY INDUSTRIES (JP) | 1999-10-13 | — | — | EP | disclosed |
| US-5683998-A | ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, ANTIPAF AGENTS | TORAY INDUSTRIES, INC. (JP) | 1997-11-04 | — | — | US | disclosed |
| US-5670511-A | Indolepiperidine derivatives | MERCK PATENT GESELLSCHAFT MIT BESCHRANKTER HAFTUNG (DE) | 1997-09-23 | — | — | US | disclosed |
| EP-0722942-A1 | Indole piperidine derivatives | MERCK PATENT GmbH (DE) | 1996-07-24 | — | — | EP | disclosed |
| EP-0536419-A1 | TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF | TORAY INDUSTRIES, INC. (JP) | 1993-04-14 | — | — | EP | disclosed |
| US-3993764-A | 3-(4*-PIPERIDYL)-INDOLES | ROUSSEL-UCLAF (FR) | 1976-11-23 | — | — | US | disclosed |
| US-3947578-A | Omega-[4-(3\"-indolyl)-piperidino]-alkyl-arylketones as nevroleptics | ROUSSEL UCLAF (FR) | 1976-03-30 | — | — | US | disclosed |