Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.70 |
| ▸ | MAPT | P10636 | 1/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.55 |
| ▸ | HTT | P42858 | 1/20 | 0.55 |
| ▸ | BRAF | P15056 | 7/20 | 0.46 |
| ▸ | FBP1 | P09467 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6996816 | 0.86 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317370 | 0.85 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6995165 | 0.84 | EGFR (0.76) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6990205 | 0.83 | EGFR (0.74) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6989673 | 0.83 | EGFR (0.74) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6993371 | 0.83 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL8317479 | 0.83 | EGFR (0.73) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6994263 | 0.83 | EGFR (0.79) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL2394914 | 0.83 | EGFR (1.00) | EGFRERBB2MAPTHPGDHTT | |
| SCHEMBL6991298 | 0.82 | EGFR (0.79) | EGFRERBB2MAPTHPGDHTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0888351-A1 | PYRIMIDO 5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | Dr. Karl Thomae GmbH (DE) | 1999-01-07 | — | — | EP | disclosed |
| WO-1997032880-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, MEDICAMENTS CONTAINING THESE COMPOUNDS, THEIR USE AND PROCESS FOR THEIR PRODUCTION | DR. KARL THOMAE GMBH (DE) | 1997-09-12 | — | — | WO | disclosed |