Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.69 |
| ▸ | ERBB2 | P04626 | 6/20 | 0.69 |
| ▸ | HPGD | P15428 | 1/20 | 0.69 |
| ▸ | HTT | P42858 | 1/20 | 0.69 |
| ▸ | AXL | P30530 | 1/20 | 0.54 |
| ▸ | ERBB4 | Q15303 | 3/20 | 0.54 |
| ▸ | MAPT | P10636 | 1/20 | 0.53 |
| ▸ | JAK3 | P52333 | 1/20 | 0.53 |
| ▸ | MAP3K8 | P41279 | 1/20 | 0.48 |
| ▸ | BRAF | P15056 | 1/20 | 0.48 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8312893 | 0.93 | EGFR (0.64) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8315059 | 0.91 | EGFR (0.60) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8314655 | 0.91 | EGFR (0.59) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL6997407 | 0.90 | EGFR (0.61) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8317682 | 0.90 | EGFR (0.70) | EGFRERBB2HPGDHTTAXL | |
| SCHEMBL6991323 | 0.90 | EGFR (0.61) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL7587577 | 0.89 | EGFR (0.57) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL8487142 | 0.89 | EGFR (0.64) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8315593 | 0.89 | EGFR (0.59) | EGFRERBB2HPGDHTTERBB4 | |
| SCHEMBL6994909 | 0.88 | EGFR (0.59) | EGFRERBB2HPGDHTTAXL |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |