SCHEMBL8317518

SCHEMBL8317518

CN(C)c1ccc(C(O)(c2ccccc2)C2CCN(CCCCl)CC2)cc1

nearest known ligand 0.60

Predicted protein targets (top 20)

geneUniProtsupporting neighboursconfidence
HRH1 P35367 6/20 0.58
KCNH2 Q12809 4/20 0.57
CYP2J2 P51589 3/20 0.56
MEN1 O00255 2/20 0.56
NPC1 O15118 1/20 0.56
CACNA1F O60840 1/20 0.56
GMNN O75496 1/20 0.56
USP2 O75604 1/20 0.56
EGFR P00533 1/20 0.56
LMNA P02545 1/20 0.56
CYP1A2 P05177 1/20 0.56
FYN P06241 1/20 0.56
CHRM2 P08172 1/20 0.56
ABCB1 P08183 1/20 0.56
CYP3A4 P08684 1/20 0.56
HTR1A P08908 1/20 0.56
ADRA2A P08913 1/20 0.56
ADORA3 P0DMS8 1/20 0.56
GAA P10253 1/20 0.56
CYP2D6 P10635 1/20 0.56

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL8315481 0.95 HRH1 (0.50) HRH1KCNH2CYP2J2MEN1NPC1
SCHEMBL16291199 0.90 KCNH2 (0.67) HRH1KCNH2CYP2J2MEN1NPC1
SCHEMBL17023773 0.83 HRH1 (0.77) HRH1KCNH2CYP2J2CYP3A4
SCHEMBL9076695 0.83 KCNH2 (0.80) HRH1KCNH2CYP2J2MEN1NPC1
SCHEMBL8316749 0.82 HRH1 (0.63) HRH1KCNH2CYP2J2MEN1NPC1
SCHEMBL11790694 0.82 CYP2J2 (0.80) HRH1KCNH2CYP2J2CYP3A4
SCHEMBL11842059 0.81 CYP2J2 (0.73) HRH1KCNH2CYP2J2CYP3A4HTR1A
SCHEMBL8317345 0.81 KCNH2 (0.54) HRH1KCNH2CYP2J2MEN1NPC1
Hydrochloric Acid SCHEMBL11543491 0.81 CYP2J2 (0.78) HRH1KCNH2CYP2J2LMNACYP3A4
SCHEMBL7439663 0.80 KCNH2 (0.51) HRH1KCNH2CYP2J2MEN1NPC1

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0536419-B1 TRICYCLIC TRIAZOLE DERIVATIVES, PRODUCTION AND USE THEREOF TORAY INDUSTRIES (JP) 1999-10-13 EP disclosed
US-5683998-A ANTIINFLAMMATORY AGENTS, ANTIALLERGENS, ANTIPAF AGENTS TORAY INDUSTRIES, INC. (JP) 1997-11-04 US disclosed
CN-1033327-C Process for preparing tricyclotriazolo derivatives and their use TORAY INDUSTRIES (JP) 1996-11-20 CN disclosed
EP-0536419-A1 TRICYCLIC TRIAZOLE DERIVATIVE, PRODUCTION THEREOF, AND USE THEREOF TORAY INDUSTRIES, INC. (JP) 1993-04-14 EP disclosed
CN-1066849-A Three ring triazolo derivatives, its Manufacturing approach and use TORAY INDUSTRIES (JP) 1992-12-09 CN disclosed