Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HTR2C | P28335 | 1/20 | 0.70 |
| ▸ | DRD2 | P14416 | 4/20 | 0.46 |
| ▸ | HTR2A | P28223 | 4/20 | 0.46 |
| ▸ | DRD3 | P35462 | 4/20 | 0.46 |
| ▸ | ABCB1 | P08183 | 1/20 | 0.46 |
| ▸ | ABCC1 | P33527 | 1/20 | 0.46 |
| ▸ | ABCG2 | Q9UNQ0 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL3681749 | 0.84 | HTR2C (0.70) | HTR2CDRD2HTR2ADRD3ABCB1 | |
| SCHEMBL616087 | 0.83 | HTR2C (1.00) | HTR2C | |
| SCHEMBL6642883 | 0.80 | HTR2C (0.65) | HTR2CDRD2HTR2ADRD3ABCB1 | |
| Hydrochloric Acid SCHEMBL7594335 | 0.79 | HTR2C (0.63) | HTR2CDRD2HTR2ADRD3ABCB1 | |
| SCHEMBL3680468 | 0.79 | HTR2C (0.63) | HTR2CDRD2HTR2ADRD3 | |
| SCHEMBL5236782 | 0.78 | HTR2C (0.62) | HTR2CDRD2HTR2ADRD3 | |
| SCHEMBL5107750 | 0.74 | HTR2C (0.70) | HTR2C | |
| SCHEMBL3678498 | 0.73 | HTR2C (0.67) | HTR2CDRD2HTR2ADRD3ABCB1 | |
| SCHEMBL3675198 | 0.71 | HTR2C (0.53) | HTR2CDRD2HTR2ADRD3 | |
| SCHEMBL3681724 | 0.71 | HTR2C (0.53) | HTR2CDRD2HTR2ADRD3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 9 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | claimed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | claimed |
| CN-1094490-C | Quinolin-2 (1H) -one derivatives as serotonin antagonists | SANOFI SYNTHELABO (FR) | 2002-11-20 | — | — | CN | disclosed |
| EP-0850235-B1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SANOFI SYNTHELABO (FR) | 1999-12-01 | — | — | EP | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |
| US-5958924-A | HYPOTENSIVE AGENTS, CARDIOVASCULAR DISORDERS, ANTIISCHEMIC AGENTS, RESTENOSIS, ANTICOALUGANTS, RESPIRATORY SYSTEM DISORDERS | SYNTHELABO (FR) | 1999-09-28 | — | — | US | disclosed |
| CN-1202168-A | Quinolein-2(1H)-one derivatives as serotonin antagonists | SYNTHELABO (FR) | 1998-12-16 | — | — | CN | disclosed |
| EP-0850235-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1998-07-01 | — | — | EP | disclosed |
| WO-1997010238-A1 | QUINOLEIN-2(1H)-ONE DERIVATIVES AS SEROTONIN ANTAGONISTS | SYNTHELABO (FR) | 1997-03-20 | — | — | WO | disclosed |