Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 12/20 | 0.70 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.70 |
| ▸ | HPGD | P15428 | 1/20 | 0.70 |
| ▸ | HTT | P42858 | 1/20 | 0.70 |
| ▸ | BTK | Q06187 | 2/20 | 0.55 |
| ▸ | JAK3 | P52333 | 1/20 | 0.55 |
| ▸ | MAPT | P10636 | 1/20 | 0.51 |
| ▸ | CSNK2A1 | P68400 | 1/20 | 0.49 |
| ▸ | MAPK3 | P27361 | 2/20 | 0.49 |
| ▸ | SYK | P43405 | 1/20 | 0.46 |
| ▸ | BRAF | P15056 | 1/20 | 0.45 |
| ▸ | CCNK | O75909 | 2/20 | 0.44 |
| ▸ | CCNA2 | P20248 | 2/20 | 0.44 |
| ▸ | CDK2 | P24941 | 2/20 | 0.44 |
| ▸ | CDK7 | P50613 | 2/20 | 0.44 |
| ▸ | CCNH | P51946 | 2/20 | 0.44 |
| ▸ | MNAT1 | P51948 | 2/20 | 0.44 |
| ▸ | CDK12 | Q9NYV4 | 2/20 | 0.44 |
| ▸ | ITK | Q08881 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8317727 | 0.95 | EGFR (0.74) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL8314697 | 0.92 | EGFR (0.68) | EGFRERBB2HPGDHTTBTK | |
| SCHEMBL6992445 | 0.88 | EGFR (0.81) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317606 | 0.87 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6998610 | 0.87 | EGFR (0.72) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL6990100 | 0.87 | EGFR (0.71) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316491 | 0.87 | EGFR (0.71) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318350 | 0.86 | EGFR (0.71) | EGFRERBB2HPGDHTTJAK3 | |
| SCHEMBL7001920 | 0.85 | EGFR (0.72) | EGFRERBB2HPGDHTTJAK3 | |
| SCHEMBL6989080 | 0.85 | EGFR (0.72) | EGFRERBB2HPGDHTTJAK3 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |