Predicted protein targets (top 7)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 17/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 2/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | MAPT | P10636 | 1/20 | 0.42 |
| ▸ | STK17A | Q9UEE5 | 2/20 | 0.41 |
| ▸ | STK17B | O94768 | 1/20 | 0.41 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8318375 | 0.91 | EGFR (0.61) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8316793 | 0.86 | EGFR (0.55) | EGFR | |
| SCHEMBL8317687 | 0.83 | EGFR (0.72) | EGFRHTT | |
| SCHEMBL8315545 | 0.82 | EGFR (0.72) | EGFR | |
| SCHEMBL8316734 | 0.82 | EGFR (0.55) | EGFRERBB2MAPTSTK17ASTK17B | |
| SCHEMBL8319402 | 0.81 | EGFR (0.52) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8314039 | 0.81 | EGFR (0.52) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8317723 | 0.79 | EGFR (0.48) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318470 | 0.79 | EGFR (0.48) | EGFRERBB2HPGDHTTMAPT | |
| SCHEMBL8318595 | 0.79 | EGFR (0.48) | EGFRERBB2HPGDHTTMAPT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |