SCHEMBL8318045

SCHEMBL8318045

CCCCOc1ccc(CN[C@@H]2CCCC[C@H]2NCc2ccc(OCCCC)cc2)cc1

nearest known ligand 0.53

Predicted protein targets (top 18)

geneUniProtsupporting neighboursconfidence
HRH3 Q9Y5N1 1/20 0.52
CYP2D6 P10635 3/20 0.51
CYP1A2 P05177 2/20 0.51
CYP2C19 P33261 1/20 0.51
TSHR P16473 1/20 0.48
KMT2A Q03164 3/20 0.47
MEN1 O00255 2/20 0.47
ALDH1A1 P00352 1/20 0.47
RAB9A P51151 1/20 0.47
KDM4E B2RXH2 3/20 0.47
SSTR3 P32745 1/20 0.46
PDE4A P27815 1/20 0.44
SMN1; SMN2 Q16637 1/20 0.44
HIF1A Q16665 1/20 0.44
HDAC10 Q969S8 1/20 0.44
HDAC6 Q9UBN7 1/20 0.44
FAAH O00519 1/20 0.44
POLB P06746 1/20 0.44

Click a target to see other patent compounds predicted against it — the reverse direction, in place.

Similar compounds — the chemically nearest patent molecules

Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.

Compoundsimilaritytop predictedshared targets
SCHEMBL5555203 0.84 HRH3 (0.58) HRH3CYP2D6CYP1A2CYP2C19TSHR
SCHEMBL3037877 0.82 S1PR5 (0.52) TSHRSSTR3
SCHEMBL8313950 0.80 SSTR3 (0.64) TSHRKMT2AMEN1ALDH1A1RAB9A
SCHEMBL3044112 0.80 S1PR5 (0.53) TSHR
SCHEMBL3269867 0.76 KDM1A (0.70)
SCHEMBL3265909 0.76 KDM1A (0.66) FAAH
SCHEMBL24316230 0.75 SSTR3 (0.58) TSHRKMT2AMEN1ALDH1A1RAB9A
SCHEMBL3268536 0.75 KDM1A (0.68)
SCHEMBL1346863 0.75 POLB (0.47) CYP2D6CYP1A2KMT2AALDH1A1KDM4E
SCHEMBL12954755 0.74 S1PR2 (0.56) CYP2D6CYP1A2TSHRKDM4EPDE4A

Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.

Patent provenance — the patents this molecule appears in, and who filed them

Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.

PatentTitleAssigneePublishedPriorityFilingCountryStatus
EP-0787716-B1 Isoprene derivatives NISSHIN FLOUR MILLING CO (JP) 1999-12-08 EP disclosed
US-5756475-A POLYISOPRENE MODIFIED WITH AMINE WITH ANTICANCER AGENTS NISSHIN FLOUR MILLING CO., LTD. (JP) 1998-05-26 US disclosed
EP-0787716-A1 Isoprene derivatives NISSHIN FLOUR MILLING CO., LTD. (JP) 1997-08-06 EP disclosed