Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | HDAC3 | O15379 | 1/20 | 0.42 |
| ▸ | HDAC1 | Q13547 | 1/20 | 0.42 |
| ▸ | HDAC2 | Q92769 | 1/20 | 0.42 |
| ▸ | HDAC6 | Q9UBN7 | 1/20 | 0.42 |
| ▸ | HDAC5 | Q9UQL6 | 1/20 | 0.42 |
| ▸ | MAPT | P10636 | 2/20 | 0.42 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.39 |
| ▸ | HPGD | P15428 | 1/20 | 0.39 |
| ▸ | MGAM | O43451 | 1/20 | 0.39 |
| ▸ | GAA | P10253 | 1/20 | 0.39 |
| ▸ | SI | P14410 | 1/20 | 0.39 |
| ▸ | MGAM2 | Q2M2H8 | 1/20 | 0.39 |
| ▸ | KDM4E | B2RXH2 | 3/20 | 0.38 |
| ▸ | HTT | P42858 | 1/20 | 0.38 |
| ▸ | TDP1 | Q9NUW8 | 1/20 | 0.36 |
| ▸ | PKM | P14618 | 1/20 | 0.36 |
| ▸ | MEN1 | O00255 | 2/20 | 0.36 |
| ▸ | KMT2A | Q03164 | 2/20 | 0.36 |
| ▸ | CYP1A2 | P05177 | 1/20 | 0.36 |
| ▸ | CYP3A4 | P08684 | 1/20 | 0.36 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL15556376 | 0.88 | MAPT (0.52) | MAPTALDH1A1HPGDKDM4ECYP1A2 | |
| SCHEMBL11226276 | 0.81 | CYP4F2 (0.47) | MAPTALDH1A1GAAKDM4ETDP1 | |
| SCHEMBL15554369 | 0.80 | KDM4E (0.40) | MAPTALDH1A1HPGDKDM4EHTT | |
| SCHEMBL8194412 | 0.79 | HSD17B10 (0.50) | MAPTALDH1A1KDM4EHTTTDP1 | |
| SCHEMBL11099629 | 0.76 | MAPT (0.37) | MAPTALDH1A1KDM4E | |
| SCHEMBL10837611 | 0.74 | MAPT (0.50) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL11433887 | 0.74 | MAPT (0.50) | MAPTALDH1A1KDM4ECYP1A2CYP3A4 | |
| SCHEMBL4766858 | 0.73 | CAPN1 (0.40) | MAPTHTTKMT2ASMN1; SMN2 | |
| SCHEMBL7159712 | 0.72 | CYP4F2 (0.64) | MGAMGAASIMGAM2TDP1 | |
| SCHEMBL8319516 | 0.71 | GAA (0.41) | HDAC3HDAC1HDAC2HDAC6HDAC5 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 2 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0900223-A1 | THIENOPYRIDINE DERIVATIVES AND THEIR USE | Takeda Chemical Industries, Ltd. (JP) | 1999-03-10 | — | — | EP | disclosed |
| WO-1997040050-A1 | THIENOPYRIDINE DERIVATIVES AND THEIR USE | TAKEDA CHEMICAL INDUSTRIES, LTD. (JP) | 1997-10-30 | — | — | WO | disclosed |