Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | CSNK2A1 | P68400 | 2/20 | 0.56 |
| ▸ | CSNK2A2 | P19784 | 1/20 | 0.56 |
| ▸ | CSNK2B | P67870 | 1/20 | 0.56 |
| ▸ | EGFR | P00533 | 13/20 | 0.49 |
| ▸ | ERBB2 | P04626 | 3/20 | 0.49 |
| ▸ | HPGD | P15428 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | FLT3 | P36888 | 1/20 | 0.48 |
| ▸ | TYRO3 | Q06418 | 1/20 | 0.48 |
| ▸ | MERTK | Q12866 | 1/20 | 0.48 |
| ▸ | GAS6 | Q14393 | 1/20 | 0.48 |
| ▸ | CDK1 | P06493 | 1/20 | 0.46 |
| ▸ | GAK | O14976 | 2/20 | 0.44 |
| ▸ | FBP1 | P09467 | 2/20 | 0.44 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.44 |
| ▸ | MAPT | P10636 | 1/20 | 0.44 |
| ▸ | RIPK2 | O43353 | 1/20 | 0.43 |
| ▸ | BUB1 | O43683 | 1/20 | 0.43 |
| ▸ | STK10 | O94804 | 1/20 | 0.43 |
| ▸ | CARS1 | P49589 | 1/20 | 0.43 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8798721 | 0.95 | CSNK2A1 (0.60) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8314852 | 0.91 | FLT3 (0.59) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8314226 | 0.91 | FLT3 (0.59) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8318103 | 0.89 | CSNK2A1 (0.62) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8319821 | 0.89 | CSNK2A1 (0.53) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8317301 | 0.88 | CSNK2A1 (0.53) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8317955 | 0.88 | CSNK2A1 (0.62) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8319176 | 0.88 | CSNK2A1 (0.53) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8314683 | 0.88 | CSNK2A1 (0.55) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 | |
| SCHEMBL8316385 | 0.87 | CSNK2A1 (0.55) | CSNK2A1CSNK2A2CSNK2BEGFRERBB2 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |