Predicted protein targets (top 5)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EGFR | P00533 | 13/20 | 0.64 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.47 |
| ▸ | RAB9A | P51151 | 1/20 | 0.47 |
| ▸ | BRAF | P15056 | 5/20 | 0.47 |
| ▸ | MKNK2 | Q9HBH9 | 1/20 | 0.44 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8315555 | 0.92 | EGFR (0.61) | EGFRBRAF | |
| SCHEMBL8320030 | 0.84 | EGFR (0.71) | EGFRKDM4ERAB9ABRAF | |
| SCHEMBL8314355 | 0.84 | EGFR (0.68) | EGFR | |
| SCHEMBL8320752 | 0.83 | EGFR (0.69) | EGFR | |
| SCHEMBL8314519 | 0.82 | EGFR (0.60) | EGFRKDM4ERAB9ABRAF | |
| SCHEMBL8314526 | 0.82 | EGFR (0.60) | EGFRKDM4ERAB9ABRAF | |
| SCHEMBL8314733 | 0.82 | EGFR (0.67) | EGFR | |
| SCHEMBL8313521 | 0.82 | EGFR (0.70) | EGFR | |
| SCHEMBL8317941 | 0.81 | EGFR (0.66) | EGFR | |
| SCHEMBL8317470 | 0.80 | EGFR (0.77) | EGFR |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 1 patent. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |