Predicted protein targets (top 19)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | EDNRA | P25101 | 12/20 | 0.56 |
| ▸ | PIK3CG | P48736 | 1/20 | 0.43 |
| ▸ | EDNRB | P24530 | 7/20 | 0.42 |
| ▸ | ABCC3 | O15438 | 1/20 | 0.41 |
| ▸ | ABCC4 | O15439 | 1/20 | 0.41 |
| ▸ | NR1I2 | O75469 | 1/20 | 0.41 |
| ▸ | ABCB11 | O95342 | 1/20 | 0.41 |
| ▸ | DHPS | P49366 | 1/20 | 0.41 |
| ▸ | NR1H3 | Q13133 | 1/20 | 0.41 |
| ▸ | NR1I3 | Q14994 | 1/20 | 0.41 |
| ▸ | MEN1 | O00255 | 3/20 | 0.40 |
| ▸ | ALDH1A1 | P00352 | 3/20 | 0.40 |
| ▸ | KMT2A | Q03164 | 3/20 | 0.40 |
| ▸ | HPGD | P15428 | 2/20 | 0.40 |
| ▸ | MAPT | P10636 | 3/20 | 0.40 |
| ▸ | PKM | P14618 | 1/20 | 0.40 |
| ▸ | TSHR | P16473 | 1/20 | 0.39 |
| ▸ | LMNA | P02545 | 1/20 | 0.39 |
| ▸ | GLA | P06280 | 1/20 | 0.39 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL8321783 | 0.96 | EDNRA (0.58) | EDNRAPIK3CGEDNRBABCC3ABCC4 | |
| SCHEMBL8324961 | 0.92 | EDNRA (0.58) | EDNRAPIK3CGEDNRBABCC3ABCC4 | |
| SCHEMBL9152792 | 0.90 | EDNRA (0.54) | EDNRAPIK3CGEDNRBMEN1ALDH1A1 | |
| SCHEMBL9152112 | 0.90 | EDNRA (0.54) | EDNRAPIK3CGEDNRBABCC3ABCC4 | |
| SCHEMBL8468582 | 0.88 | EDNRA (0.55) | EDNRAPIK3CGEDNRBABCC3ABCC4 | |
| SCHEMBL9154629 | 0.88 | EDNRA (0.51) | EDNRAEDNRBMEN1ALDH1A1KMT2A | |
| SCHEMBL8328509 | 0.87 | EDNRA (0.55) | EDNRAEDNRB | |
| SCHEMBL8327799 | 0.86 | EDNRA (0.57) | EDNRAPIK3CGEDNRBABCC3ABCC4 | |
| SCHEMBL8322059 | 0.85 | EDNRA (0.56) | EDNRAPIK3CGEDNRBMEN1ALDH1A1 | |
| SCHEMBL9092481 | 0.85 | EDNRA (0.55) | EDNRAPIK3CGEDNRBABCC3ABCC4 |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0633259-B1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | HOFFMANN LA ROCHE (CH) | 1999-01-13 | — | — | EP | disclosed |
| US-5541186-A | ENDOTHELIN RECEPTOR INHIBITORS | HOFFMANN-LA ROCHE INC. (US) | 1996-07-30 | — | — | US | disclosed |
| EP-0633259-A1 | Sulfonylaminopyrimidines, their preparation and their use as medicine | F. HOFFMANN-LA ROCHE AG (CH) | 1995-01-11 | — | — | EP | disclosed |