Predicted protein targets (top 20)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | MAPT | P10636 | 5/20 | 0.58 |
| ▸ | SMN1; SMN2 | Q16637 | 2/20 | 0.58 |
| ▸ | LMNA | P02545 | 2/20 | 0.58 |
| ▸ | POLB | P06746 | 1/20 | 0.58 |
| ▸ | HPGD | P15428 | 3/20 | 0.57 |
| ▸ | BRAF | P15056 | 4/20 | 0.52 |
| ▸ | EGFR | P00533 | 3/20 | 0.50 |
| ▸ | KDM4E | B2RXH2 | 1/20 | 0.50 |
| ▸ | NPC1 | O15118 | 1/20 | 0.50 |
| ▸ | RAB9A | P51151 | 1/20 | 0.50 |
| ▸ | MAPKAPK2 | P49137 | 1/20 | 0.50 |
| ▸ | ERBB2 | P04626 | 1/20 | 0.49 |
| ▸ | HTT | P42858 | 1/20 | 0.49 |
| ▸ | TP53 | P04637 | 4/20 | 0.48 |
| ▸ | CSNK2A1 | P68400 | 4/20 | 0.47 |
| ▸ | THRB | P10828 | 1/20 | 0.46 |
| ▸ | CSNK2A2 | P19784 | 3/20 | 0.46 |
| ▸ | CSNK2B | P67870 | 3/20 | 0.46 |
| ▸ | ALDH1A1 | P00352 | 1/20 | 0.46 |
| ▸ | CSNK2A3 | Q8NEV1 | 1/20 | 0.46 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL7580907 | 0.84 | EGFR (0.55) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8318379 | 0.83 | EGFR (0.55) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8313532 | 0.83 | EGFR (0.56) | MAPTSMN1; SMN2LMNAHPGDBRAF | |
| SCHEMBL7581241 | 0.82 | EGFR (0.55) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL7577862 | 0.82 | CSNK2A1 (0.51) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8319428 | 0.82 | EGFR (0.73) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8314008 | 0.80 | EGFR (0.60) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8314004 | 0.80 | EGFR (0.60) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8318922 | 0.80 | EGFR (0.62) | HPGDBRAFEGFRERBB2HTT | |
| SCHEMBL8318928 | 0.80 | EGFR (0.62) | HPGDBRAFEGFRERBB2HTT |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 3 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0779888-B1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | BOEHRINGER INGELHEIM PHARMA (DE) | 1999-04-28 | — | — | EP | disclosed |
| EP-0779888-A1 | PYRIMIDO [5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | Dr. Karl Thomae GmbH (DE) | 1997-06-25 | — | — | EP | disclosed |
| WO-1996007657-A1 | PYRIMIDO[5,4-D]PYRIMIDINES, DRUGS CONTAINING THESE COMPOUNDS, THEIR USE, AND PROCESS FOR PREPARING THEM | DR. KARL THOMAE GMBH (DE) | 1996-03-14 | — | — | WO | disclosed |