Predicted protein targets (top 10)
| gene | UniProt | supporting neighbours | confidence | |
|---|---|---|---|---|
| ▸ | SOAT1 | P35610 | 7/20 | 0.38 |
| ▸ | GPR84 | Q9NQS5 | 2/20 | 0.35 |
| ▸ | SOAT2 | O75908 | 1/20 | 0.34 |
| ▸ | ACAT1 | P24752 | 1/20 | 0.34 |
| ▸ | LMNA | P02545 | 1/20 | 0.31 |
| ▸ | PPARA | Q07869 | 2/20 | 0.31 |
| ▸ | PPARG | P37231 | 1/20 | 0.31 |
| ▸ | GAA | P10253 | 1/20 | 0.31 |
| ▸ | HTT | P42858 | 1/20 | 0.31 |
| ▸ | SMN1; SMN2 | Q16637 | 1/20 | 0.31 |
Click a target to see other patent compounds predicted against it — the reverse direction, in place.
Similar compounds — the chemically nearest patent molecules
Nearest neighbours by Morgan-fingerprint cosine across the patent-compound collection, with each neighbour's top predicted target and the predicted targets it shares with this molecule.
| Compound | similarity | top predicted | shared targets | |
|---|---|---|---|---|
| SCHEMBL6123211 | 1.00 | SOAT1 (0.38) | SOAT1GPR84SOAT2ACAT1LMNA | |
| SCHEMBL8321431 | 1.00 | SOAT1 (0.38) | SOAT1GPR84SOAT2ACAT1LMNA | |
| SCHEMBL29427721 | 1.00 | SOAT1 (0.38) | SOAT1GPR84SOAT2ACAT1LMNA | |
| SCHEMBL8322961 | 0.93 | SOAT1 (0.36) | SOAT1LMNAPPARAPPARG | |
| SCHEMBL8325248 | 0.90 | SOAT1 (0.37) | SOAT1GPR84LMNAPPARAPPARG | |
| SCHEMBL8323636 | 0.86 | SOAT1 (0.38) | SOAT1LMNA | |
| SCHEMBL9225723 | 0.85 | SOAT1 (0.38) | SOAT1GPR84 | |
| SCHEMBL8323242 | 0.85 | EPHX1 (0.34) | SOAT1SOAT2ACAT1LMNAPPARA | |
| SCHEMBL8322453 | 0.85 | EPHX1 (0.34) | SOAT1SOAT2ACAT1LMNAPPARA | |
| SCHEMBL8327680 | 0.85 | EPHX1 (0.34) | SOAT1SOAT2ACAT1LMNAPPARA |
Similarity is cosine over the 2,048-bit Morgan fingerprint (≈ Tanimoto). Identical fingerprints score 1.00.
Patent provenance — the patents this molecule appears in, and who filed them
Claimed or disclosed in 5 patents. claimed = in the patent's claims; disclosed = body only.
| Patent | Title | Assignee | Published | Priority | Filing | Country | Status |
|---|---|---|---|---|---|---|---|
| EP-0609960-B1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER (US) | 1999-03-03 | — | — | EP | disclosed |
| US-5656634-A | N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1997-08-12 | — | — | US | disclosed |
| US-5362878-A | Intermediates for making N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase (ACAT) | PFIZER INC. (US) | 1994-11-08 | — | — | US | disclosed |
| EP-0609960-A1 | New N-heteroarylamide derivatives as inhibitors of acyl coenzyme A: cholestrol acyl transferase | PFIZER INC. (US) | 1994-08-10 | — | — | EP | disclosed |
| EP-0418071-A2 | New N-aryl and N-heteroarylamide and urea derivatives as inhibitors of acyl coenzyme A: cholesterol acyl transferase | PFIZER INC. (US) | 1991-03-20 | — | — | EP | disclosed |